Investigation of Protein and Polymer as a Carrier on Immune System

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Authors

  • Banu MANSUROGLU
  • Serap DERMAN
  • Kadriye KIZILBEY
  • Zeynep MUSTAFAEVA AKDESTE

Keywords:

Polyelectrolyte, biopolymer systems, immunogen, polymer-peptide conjugates, synthetic vaccine, foot-andmouth disease virus.

Abstract

The immunogenic properties of water soluble BSA-Peptide and VP/AA-Peptide conjugates were investigated, and
specificity of antibodies produced was analyzed. This epitope of Foot-and Mouth Disease virus VP1 protein (135-161 amino
acid sequences) were used as a polypeptide antigen. Immunogenic activity of BSA-Peptide and VP/AA-Peptide conjugates
were investigated depending on the peptide amount in conjugates per mouse and carrier (synthetic polyelectrolyte or protein
molecule) structure. VP/AA-Peptide and BSA-Peptide conjugates revealed very high immunogenicity which are different in
regards to the specificity of the antibody produced. The BSA-Peptide conjugates were able to generate specific antibodies
both for 135-161 peptide epitope and BSA. In contrast to VP/AA-Peptide conjugates system was able to generate only 135-
161 peptide epitope antibodies.

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Published

2019-07-15

How to Cite

MANSUROGLU, B., DERMAN, S., KIZILBEY, K., & AKDESTE, Z. M. (2019). Investigation of Protein and Polymer as a Carrier on Immune System. International Journal of Natural and Engineering Sciences, 3(2), 35–38. Retrieved from https://ijnes.org/index.php/ijnes/article/view/480

Issue

Vol. 3 No. 2 (2009): 2009-2

Section

Articles