Basic Fibroblast Growth Factor Retains Its Biological Activity In Vitro When Delivered Through Degradation of Gelatin Microspheres

Abstract

In designing delivery systems for growth factors and other protein drugs, it is important to know what percentage of the loaded protein will be
delivered in biologically active form. This work evaluates the release system of basic fibroblast growth factor (bFGF) through gelatin microspheres.
The results indicate that there is no detectable loss of mitogenic activity of the growth factor on fibroblastic cells after delivery.